Project 1

1. Applicant

2. Topic

Regulation of YB-1 expression and activity in melanoma cells

3. Short summary

Y-box binding protein 1 (YB-1) is a member of the cold shock domain (CSD) protein family and regulates transcription and translation by binding to RNA and DNA. YB-1 controls the expression of genes involved in cell proliferation, migration, DNA replication and drug resistance. Our own data show that YB-1 expression is upregulated and the protein is translocated to the nucleus during melanoma progression, and that YB-1 is an important transcription factor regulating proliferation, survival, migration, invasion and chemosensitivity of melanoma cells. However, the mechanisms governing the expression and activity of YB-1 during melanoma progression are still not known. Therefore, the goals of our research project are a) to identify the factors which regulate the expression, nuclear translocation and functional activities of YB-1 in melanoma cells and b) to investigate whether YB-1 overexpression is an early event in malignant transformation of melanocytes and melanoma metastases formation. The results of our study should indicate to what extent YB-1 is involved in melanoma progression and whether YB-1 may be a molecular target in melanoma therapy.

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