New project 3

1. Applicant

2. Topic

Role of oncogene-induced senescence in melanoma pathogenesis

3. Short summary

Oncogene-induced senescence is regarded as a potent tumor suppressor mechanism which circumvents cellular proliferation and thereby potently prevents tumor formation. It is hypothesized that deregulation of the senescence program is a key event in the development of melanoma. The objective of this project is to unravel novel molecular determinants that regulate the senescence response in primary human melanocytes. These molecules are likely to be representative of pathways critical in the genesis of melanoma and to the rational approach to targeted therapy.

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