New project 1

1. Applicant

2. Topic

Characterization of the role of SOX transcription factors in melanoma

3. Short summary

Molecules exclusively expressed in embryogenesis regulate processes, such as proliferation, differentiation, and migration, which are also important in cancer development and progression. During embryogenesis melanocytes develop from neural crest cells and express SOX (Sry HMG-box) transcription factors, among which the SOXE group members, SOX9 and SOX10, play a central role. Expression of both proteins has been detected in melanoma and this project will focus on their involvement in tumor progression and on their suggested target genes, also with respect to co-regulatory factors, such as SOX5 and PAX3.

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